Monday, June 23, 2008

Drugs, Pain and You and You and You

First off a little education about "Pain Killers".

Really want pain killers? Real pain relief? "literally Anaesthesia". General Anaesthesia is more akin to a controlled drug overdose and local anaesthesia like the dentist shoots in your gum takes many forms, It directly affects how nerves work, motor and sensory. Athletes "shot up for a game" like a football player, might get this.

Narcotics or Opiods - Morphine, heroin, oxycodone, hydrocodone, Oxycontin (Time-released multiple doses of oxycodone - Rush L.'s drug of hypocritic downfall) are in their effects not very dissimilar to drinking heavily, making you less aware or less attached to your pain. If you do something really painful, like move a broken long bone while on narcotics, you'll still feel it, you'll just care less and for less time - you're basically distracted. that's why these are properly referred to as sedative hypnotics.

Ibuprofen (in all forms since it's now generic), Celebrex, Bextra, Naproxen, Vioxx, Sulindac, - these are not pain killers. Yes they have some direct pain reducing properties as do aspirin (None exceed it but have arguably better side effect profiles) but they primarily help musculo-skeletal pain by reducing inflammation (Anti-Inflammatories, NSAID's). Certainly they don't mask anything. If you have acute pains, they just make them a little less, perhaps. They mostly help dull, aching pain except that of spasms - for which almost nothing works. These work by blocking inflammation mediators, the old ones - Aspirin, Ibuprofen, Naproxen are all shotgun, i.e. COX 1 & 2. Cox 2's have a very checkered history of complications, some deeply suppressed, some come to light (hypertension (^ BP) and frank cardiac problems including death rates increased enough to consider cause-effect relationships. Just an aside about "side effects". All drugs have effects and side effects, the "side effects are just the ones we don't like.)

So anyway, I've heard a lot of folks with various amounts of credibility apply all this to El Tigre. what can we surmise?

- We know he wasn't given general anaesthesia

- It's unlikely he had local anaesthesia; there's be too much risk of unintended consequences if he hadn't tried it beforehand. No evidence to either side, just applying good reasoning. I also personally think it would border on unethical for the administrator of the local anesthesia blocks unless a licensed doctor or P.A. or N.P.. Any of these travel with Tiger?

- Opiates? Why not, who hasn't played with a beer or two on board? Heck, some social players I have played with weren't at their best until at least their third drink (by the second hole).

- NSAIDS almost certainly. Your guess is as good as mine, they're all second to Aspirin in absolute efficacy, though. Let me repeat that: All the billions of $, £, and € spent on NSAIDS, none is more effective than good old Willow tree Bark's aspirin.

Conspire away.

Anyone tired of Tiger's Knee yet? :)

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